Research Update in
Neuroscience for Neurosurgeons

V. Reggie Edgerton
UCLA Medical Center

"Activity Dependent Mechanisms that Enhance Sensorimotor Function Following Spinal Cord Injury"

1. Nature Medicine - 12, 790 - 792 (2006)
   Published online: 2 July 2006; Corrected online: 13 September 2006 | doi:10.1038/nm1436
   Nogo-A-specific antibody treatment enhances sprouting and functional recovery after cervical lesion in adult primates
   Patrick Freund1, 5, Eric Schmidlin1, 5, Thierry Wannier1, 2, 5, Jocelyne Bloch3, Anis Mir4, Martin E Schwab2 & Eric M Rouiller 1
   
   • Unit of Physiology and Program in Neurosciences, Department of Medicine, Faculty of Sciences, University of Fribourg, Chemin du Musée 5, CH-1700 Fribourg, Switzerland.
     
   • Brain Research Institute, University of Zürich, Department of Biology, ETH Zürich, Winterthurerstr. 190, CH-8057 Zürich, Switzerland.
     
   • Department of Neurosurgery, Neurosurgery Clinic, University Hospital of Lausanne, Rue du Bugnon, CH-1011 Lausanne, Switzerland.
     
   • Neuroscience Research, Novartis Institute for BioMedical Research, CH-4002 Basel, Switzerland.
     
   • These authors contributed equally to the study.
     Correspondence should be addressed to Eric M Rouiller Eric.Rouiller@unifr.ch

   
   
2. Cai, L.L., Fong, A.J., Otoshi, C.K., Liang, Y.Q., Cham, J.G., Zhong, H., Roy, R.R., Edgerton, V.R., and Burdick, J.W. Effects of consistency vs. variability in robotically controlled training of stepping in adult spinal mice. Proc. Int. Conference Rehab. Robotics. pp. 575-579, 2005.
   
   
3. Courtine, G., Roy, R.R., Hodgson, J., McKay, H.,, Raven, J., Zhong, H., Yang, H., Tuszynski, M.H., and Edgerton, V.R. Kinematic and EMG determinants in quadrupedal locomotion of a non-human primate (Rhesus). J. Neurophysiol. 93(6):3127-45. 2005
   
   
4. Gomez-Pinilla, F., Ying, Z., Roy, R.R., Hodgson, J.A., and Edgerton, V.R. Afferent input modulates neurotrophins and synaptic plasticity in the spinal cord. J. Neurophysiol. 92:3423-3432, 2004.
   
   
5. Edgerton, V.R., Tillakaratne, N.J.T., Bigbee, A.J., de Leon, R.D. and Roy, R.R. Plasticity of the spinal circuitry after injury. Ann. Rev. Neurosci. 27:145-167, 2004.
   
   
6. Timoszyk, W.K., de Leon, R.D., London, N., Roy, R.R., Edgerton, V.R., Reinkensmeyer, D.J. The Rat Lumbosacral Spinal Cord Adapts to Robotic Loading Applied During Stance. J. Neurophysiology, 88:3108-3117, 2002.
   
   
7. Edgerton, V.R., and Roy, R.R. Paralysis recovery in humans and model systems. Curr. Opinion Neurobiol. 12:658-667, 2002.
   
   
8. Maegele, M., Harkema, S.J., Muller, S., Wernig, A., and Edgerton, V.R. Recruitment of spinal motor pools during voluntary movements versus stepping after human spinal cord injury. J. Neurotrauma. 19 (10):1217-1229, 2002
   
   
9. Dietz V,and Harkema SJ. Locomotor activity in spinal cord-injured persons. J Appl Physiol. 96(5):1954-60. Review, 2004
   
   
10. Beres-Jones JA, and Harkema SJ. The human spinal cord interprets velocity-dependent afferent input during stepping. Brain. 127(10):2232-46, 2004

Links to PDFs

1. Tipton Chapter Figures
   
   
2. Plasticity Of The Spinal Neural Circuitry After Injury
   
   
3. Hindlimb Locomotor and Postural Training Modulates Glycinergic Inhibition in the
   Spinal Cord of the Adult Spinal Cat
   
   
4. Topical Review Retraining the injured spinal cord
   
   
5. Effects Of Consistency vs. Variabilty In Robotically Controlled Training Of Stepping In
   Adult Spinal Mice
   
   
6. Kinematic and EMG Determinants in Quadrupedal Locomotion of a Non-Human Primate (Rhesus)
   
   
7. Afferent Input Modulates Neurotrophins and Synaptic Plasticity in the Spinal Cord
   
   
8. The Rat Lumbosacral Spinal Cord Adapts to Robotic Loading Applied During Stance
   
   
9. Paralysis recovery in humans and model systems V Reggie Edgerton and Roland R Roy
   
   
10. Recruitment of Spinal Motor Pools during Voluntary Movements versus Stepping after Human Spinal Cord Injury
    
    
11. Locomotor activity in spinal cord-injured persons
    
    
12. The human spinal cord interprets velocity-dependent afferent input during stepping
    
    

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