Research Update in
Neuroscience for Neurosurgeons

Robert Friedlander
Harvard Medical School

"Mechanisms of Cell Death in Neurologic Diseases"

1. Minocycline inhibits caspase-independent and caspase-dependent mitochondrial cell death pathways in models of Huntington's disease. Xin W, Zhu S, Drozda M, Zhang W, Stavrovskaya IG, Cattaneo E, Ferrante RJ, Kristal BS, Friedlander RM. Proceedings of the National Academy of Sciences 100, 10483-10487 (2003).
   
   
2. Additive neuroprotective effects of minocycline with creatine in a transgenic mouse model of ALS. Zhang, W, Narayanan M, Friedlander RM. Annals of Neurology. 53, 267-270 (2003).
   
   
3. Minocycline inhibits cytochrome c release and delays progression of ALS in mice. Zhu S, Stavrovskaya IG, Drozda M, Kim BYS, Ona V, Li M, Sarang S, Liu AS, Hartley DM, Wu DC, Gullans S, Ferrante RJ, Przedborski S, Kristal BS, Friedlander RM. Nature 417, 74-78 (2002).
   
   
4. Minocycline reduces traumatic brain injury-mediated caspase-1 activation, tissue damage, and neurologic dysfunction. Sanchez-Mejia RO, Ona VO, Li M, Friedlander RM. Neurosurgery 48, 1393-1399 (2001).
   
   
5. Functional role and therapeutic implications of neuronal caspase-1 and -3 in a mouse model of traumatic spinal cord injury. Li M, Ona VO, Chen M, Kaul M, Tenneti L, Stieg PE, Lipton SA, Friedlander RM. Neuroscience 99, 333-342 (2000).
   
   
6. Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington's disease. Chen M, Ona VO, Li M, Ferrante RJ, Fink KB, Zhu S, Bian J, Guo L, Farrell LA, Hersch SM, Hobbs W, Vonsattel JP, Cha J-HC, Friedlander RM. Nature Medicine 6, 797-801 (2000).
   
   
7. Reduction of Post-traumatic Brain Injury and Free Radical production by inhibition of the Caspase cascade. Fink KB, Andrews LJ, Butler WE, Ona VO, Li M, Bogdanov M, Endres M, Khan SQ, Namura S, Stieg PE, Beal MF, Moskowitz MA, Yuan J, Friedlander RM. Neuroscience 94, 1213-1218, 1999.
   
   
8. Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model. Li M, Ona VO, Guegan C, Chen M, Jackson-Lewis V, Andrews LJ, Olszewski A, Stieg PE, Lee JP, Przedborski S, Friedlander RM. Science 288, 335-339, 2000.
   
   
9. Ona V, Li M, Vonsattel J-PG, Andrews LJ, Khan SQ, Chung WM, Frey AS, Menon AS, Li XJ, Stieg PE, Yuan J, Penney JB, Young AB, Cha J-HC, Friedlander RM. Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease. Nature 399, 263-267, 1999.
   
   
10. Friedlander, R.M.; Brown, RH; Gagliardini, V; Wang, J; Yuan, J. Inhibition of ICE slows ALS in mice. Nature, 388, 31, 1997.
    
    
11. Friedlander, R.M.; Gagliardini, V.; Hara, H; Fink, KB; Li, W; MacDonald, G; Fishman, MC; Greenberg, AH; Moskowitz, MA; and Yuan, J. Expression of a dominant negative mutant of ICE in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injury. J Experimental Medicine, 185, 933-940, 1997.

Reviews

1. Friedlander, R. M. Role of Caspase-1 in Neurologic Disease. Archives of Neurology 57, 1273-1276, 2000.
   
   
2. Sanchez Mejia R, Friedlander, R. M. Functional Role of Caspases in Huntington's disease. The Neuroscientist 7, 480-489, 2001.
   
   
3. Friedlander R. M. Role of Programmed Cell Death in Neurologic Disease. New England Journal of Medicine 348, 1365-1375, 2003.

Copyright © 2008 The Society of Neurological Surgeons