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  • Chairman of Neurosurgery
    Harvey Cushing Professor of Neurosurgery
    Professor of Oncology and Ophthalmology
    The Johns Hopkins Hospital
    Department of Neurosurgery

    Lecture Title: “Brain Tumor Therapy”

    READING LIST:

    1. Sampath P1, Long DM, Brem H. The Hunterian Neurosurgical Laboratory: the first 100 years of neurosurgical research. Neurosurgery. 2000 Jan;46(1):184-94; discussion 194-5.
    2. Tyler BM, Liu A, Sankey EW, Mangraviti A, Barone MA, Brem H. The Johns Hopkins Hunterian Laboratory Philosophy: Mentoring Students in a Scientific Neurosurgical Research Laboratory. Acad Med. 2016 Jun;91(6):778-84. PMID: 26934692 [PubMed - in process]
    3. Brem H, Sankey EW, Liu A, Mangraviti A, Tyler BM. Developing Therapies for Brain Tumors: The Impact of the Johns Hopkins Hunterian Neurosurgical Research Laboratory. Trans Am Clin Climatol Assoc. 2017;128:55-74.
    4. Brem H, Piantadosi S, Burger PC, Walker M, Selker R, Vick NA, Black K, Sisti M, Brem S, Mohr G. Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas. The Polymer-brain Tumor Treatment Group. Lancet. 1995; 345(8956): 1008-1012. PMID 7723496.
    5. Piccirillo SG, Reynolds BA, Zanetti N, Lamorte G, Binda E, Broggi G, Brem H, Olivi A, Dimeco F, Vescovi AL. Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells. Nature. 2006; 444(7120): 761-765. PMID 17151667.
    6. Brem H, Mahaley MS,Jr, Vick NA, Black KL, Schold SC,Jr, Burger PC, Friedman AH, Ciric IS, Eller TW, Cozzens JW. Interstitial chemotherapy with drug polymer implants for the treatment of recurrent gliomas. J.Neurosurg. 1991; 74(3): 441-446. PMID 1993909.
    7. Brem H and Folkman J. Inhibition of tumor angiogenesis mediated by cartilage. J.Exp.Med. 1975; 141(2): 427-439. PMID 1113064. PMC2190537.
    8. Richards Grayson AC, Choi IS, Tyler BM, Wang PP, Brem H, Cima MJ, Langer R. Multi-pulse drug delivery from a resorbable polymeric microchip device. Nat.Mater. 2003; 2(11): 767-772. PMID 14619935.
    9. Bettegowda C, Sausen M, Leary RJ, et al. Detection of circulating tumor DNA in early- and late-stage human malignancies. Sci Transl Med. 2014 Feb 19;6(224):224ra24. doi: 10.1126/scitranslmed.3007094.
    10. Upadhyay UM,Tyler BM, Patta YR,Wicks RT, Spencer KC, Scott AW, Masi B, Hwang LS, Grossman R, Cima M, Brem H, Langer R. Intracranial Microcapsule Chemotherapy Delivery for the Localized Treatment of Rodent Metastatic Breast Adenocarcinoma in the Brain. Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):16071-6. PMC4234553
    11. Chaichana KL, Kone L, Bettegowda C, Weingart JD, Olivi A, Lim M, Quinones-Hinojosa A, Gallia GL, Brem H. Risk of surgical site infection in 401 consecutive patients with glioblastoma with and without carmustine wafer implantation. Neurol Res. 2015 Aug;37(8):717-26. PMID:25916669.
    12. Wang Y, Springer S, Zhang M, et al. Detection of tumor-derived DNA in cerebrospinal fluid of patients with primary tumors of the brain and spinal cord. Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):9704-9. PMC4534284
    13. Mangraviti A, Gullotti D, Tyler B, Brem H. Nanobiotechnology-based delivery strategies: New frontiers in brain tumor targeted therapies. J Control Release. 2016 Mar 23. pii: S0168-3659(16)30165-1. PMID: 27016141.
    14. Mathios D, Kim JE, Mangraviti A, Phallen J, Park CK, Jackson CM, Garzon-Muvdi T, Kim E, Theodros D, Polanczyk M, Martin AM, Suk I, Ye X, Tyler B, Bettegowda C, Brem H, Pardoll DM, Lim M. Anti-PD-1 antitumor immunity is enhanced by local and abrogated by systemic chemotherapy in GBM. Sci Transl Med. 2016 Dec 21;8(370):370ra180. doi: 10.1126/scitranslmed.aag2942.
    15. Sonabend AM, Zacharia BE, Cloney MB, Sonabend A, Showers C, Ebiana V, Nazarian M, Swanson KR, Baldock A, Brem H, Bruce JN, Butler W, Cahill DP, Carter B, Orringer DA, Roberts DW, Sagher O, Sanai N, Schwartz TH, Silbergeld DL, Sisti MB, Thompson RC, Waziri AE, Ghogawala Z, McKhann G 2nd. Defining Glioblastoma Resectability Through the Wisdom of the Crowd: A Proof-of-Principle Study. Neurosurgery. 2017 Apr 1;80(4):590-601. doi: 10.1227/NEU.0000000000001374.
    16. Nabors LB, Portnow J, Ammirati M, et al. NCCN Guidelines Insights: Central Nervous System Cancers, Version 1.2017. J Natl Compr Canc Netw. 2017 Nov;15(11):1331-1345. doi: 10.6004/jnccn.2017.0166
    17. Mangraviti A, Raghavan T, Volpin F, et al. HIF-1?- Targeting Acriflavine Provides Long Term Survival and Radiological Tumor Response in Brain Cancer Therapy. Sci Rep. 2017 Nov 2;7(1):14978. doi: 10.1038/s41598-017-14990-w
    18. Hung AL, Maxwell R, Theodros D, et al. TIGIT and PD-1 dual checkpoint blockade enhances antitumor immunity and survival in GBM. Oncoimmunology. 2018 May 24;7(8):e1466769. doi: 10.1080/2162402X.2018.1466769. eCollection 2018
    19. Gordon CR, Santiago GF, Huang J, Bergey GK, Liu S, Armand M, Brem H, Anderson WS. First In-Human Experience With Complete Integration of Neuromodulation Device Within a Customized Cranial Implant. Oper Neurosurg (Hagerstown). 2018 Jul 1;15(1):39-45. doi: 10.1093/ons/opx210
    20. Harris-Bookman S, Mathios D, Martin AM, et al. Expression of LAG-3 and efficacy of combination treatment with anti-LAG-3 and anti-PD-1 monoclonal antibodies in glioblastoma. Int J Cancer. 2018 Dec 15;143(12):3201-3208. doi: 10.1002/ijc.31661. Epub 2018 Sep 24
    21. Gordon CR, Wolff A, Santiago GF, Liebman K, Veznedaroglu E, Vrionis FD, Huang J, Brem H, Luciano M. First-in-Human Experience With Integration of a Hydrocephalus Shunt Device Within a Customized Cranial Implant. Oper Neurosurg (Hagerstown). 2019 Feb 7. doi: 10.1093/ons/opz003. [Epub ahead of print]
    22. Shapira-Furman T, Serra R, Gorelick N, Doglioli M, Tagliaferri V, Cecia A, Peters M, Kumar A, Rottenberg Y, Langer R, Brem H, Tyler B, Domb AJ. Biodegradable wafers releasing Temozolomide and Carmustine for the treatment of brain cancer. J Control Release. 2019 Feb 10;295:93-101. doi: 10.1016/j.jconrel.2018.12.048. Epub 2018 Dec 31.
    23. Belzberg M, Shalom NB, Lu A, Yuhanna E, Manbachi A, Tekes A, Huang J, Brem H, Gordon C. Transcranioplasty Ultrasound Through a Sonolucent Cranial Implant Made of Polymethyl Methacrylate: Phantom Study Comparing Ultrasound, Computed Tomography, and Magnetic Resonance Imaging. J Craniofac Surg. 2019 Jun 7. doi: 10.1097/SCS.0000000000005651. [Epub ahead of print]
    24. Casaos J, Gorelick NL, Huq S, Choi J, Xia Y, Serra R, Felder R, Lott T, Kast RE, Suk I, Brem H, Tyler B, Skuli N. The Use of Ribavirin as an Anticancer Therapeutic: Will It Go Viral? Mol Cancer Ther. 2019 Jul;18(7):1185-1194. doi: 10.1158/1535-7163.MCT-18-0666
    25. Mathios D, Hwang T, Xia Y, Phallen J, Rui Y, See AP, Maxwell R, Belcaid Z, Casaos J, Burger PC, McDonald KL, Gallia GL, Cope L, Kai M, Brem H, Pardoll DM, Ha P, Green JJ, Velculescu VE, Bettegowda C, Park CK, Lim M. Genome-wide investigation of intragenic DNA methylation identifies ZMIZ1 gene as a prognostic marker in glioblastoma and multiple cancer types. Int J Cancer. 2019 Aug 2. doi: 10.1002/ijc.32587. [Epub ahead of print]