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  • J. Marc Simard, M.D.,Ph.D.

  • Professor of Neurosurgery, University of Maryland
    Professor of Pathology, University of Maryland
    Professor of Physiology, University of Maryland
    Chief of Neurological Service, Baltimore V.A. Medical Center, Baltimore, MD

    "The SUR1-TRPM4 Channel - a Critical Player in CNS Ischemia and Trauma"

    Outline

    1. Basic properties of the SUR1-TRPM4 channel
      1. electrophysiology
      2. pharmacology
      3. molecular biology
    1. Cellular consequences of channel opening
      1. depolarization
      2. cytotoxic edema
      3. oncotic (necrotic) cell death
    1. Channel up-regulation in CNS injury
      1. cerebral ischemia
      2. traumatic brain injury
    1. Channel blockade in CNS injury
      1. Cerebral ischemia
      2. traumatic brain injury

    Suggested reading:

    1. Sulfonylurea Receptor 1 in Central Nervous System Injury: A Focused Review
      Journal of Cerebral Blood Flow & Metabolism (2012): 1-19.

    2. Glibenclamide in Cerebral Ischemia and Stroke
      Neurocrit Care (2014) 20:319–333 DOI 10.1007/s12028-013-9923-1

    3. Long-Term Outcomes in Patients Aged =70 Years With Intravenous Glyburide From the Phase II GAMES-RP Study of Large Hemispheric Infarction: An Exploratory Analysis. Stroke (2018)


    4. SUR1-TRPM4 and AQP4 form a heteromultimeric complex that amplifies ion/water osmotic coupling and drives astrocyte swelling. Glia (2018)

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