J. Marc Simard, M.D.,Ph.D.

Professor of Neurosurgery, University of Maryland
Professor of Pathology, University of Maryland
Professor of Physiology, University of Maryland
Chief of Neurological Service, Baltimore V.A. Medical Center, Baltimore, MD

"The SUR1-TRPM4 Channel - a Critical Player in CNS Ischemia and Trauma"

Outline

1. Basic properties of the SUR1-TRPM4 channel
   1. electrophysiology
   2. pharmacology
   3. molecular biology

2. Cellular consequences of channel opening
   1. depolarization
   2. cytotoxic edema
   3. oncotic (necrotic) cell death

3. Channel up-regulation in CNS injury
   1. cerebral ischemia
   2. traumatic brain injury

4. Channel blockade in CNS injury
   1. Cerebral ischemia
   2. traumatic brain injury

Suggested reading:

1. Sulfonylurea Receptor 1 in Central Nervous System Injury: A Focused Review
   Journal of Cerebral Blood Flow & Metabolism (2012): 1-19.
   
   
2. Glibenclamide in Cerebral Ischemia and Stroke
   Neurocrit Care (2014) 20:319–333 DOI 10.1007/s12028-013-9923-1
   
   
3. Long-Term Outcomes in Patients Aged =70 Years With Intravenous Glyburide From the Phase II GAMES-RP Study of Large Hemispheric Infarction: An Exploratory Analysis. Stroke (2018)
   
   
   
4. SUR1-TRPM4 and AQP4 form a heteromultimeric complex that amplifies ion/water osmotic coupling and drives astrocyte swelling. Glia (2018)