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  • Professor and Head, Department of Clinical Neurosciences
    Calgary Zone, Alberta Health Services
    Scientist, Hotchkiss Brain Institute
    Cumming School of Medicine, University of Calgary

    Lecture Title: "Peripheral Nerve Regeneration and Repair: Possibilities and Challenges"

    Selected key references for following topics:

    General references on nerve regeneration, evaluation and outcomes 1 2

    Nerve regeneration biology 3 4

    Nerve conduits and tubes 5 6 7

    Cell therapy in nerve repair 8

    Clinical nerve repair and nerve transfers 9 10

    1. Palispis, W. A. & Gupta, R. Surgical repair in humans after traumatic nerve injury provides limited functional neural regeneration in adults. Exp Neurol 290, 106-114, doi:10.1016/j.expneurol.2017.01.009 (2017).
    2. Kemp, S. W., Cederna, P. S. & Midha, R. Comparative outcome measures in peripheral regeneration studies. Exp Neurol 287, 348-357, doi:10.1016/j.expneurol.2016.04.011 (2017).
    3. Jessen, K. R. & Mirsky, R. The repair Schwann cell and its function in regenerating nerves. J Physiol 594, 3521-3531, doi:10.1113/JP270874 (2016).
    4. Painter, M. W. et al. Diminished Schwann cell repair responses underlie age-associated impaired axonal regeneration. Neuron 83, 331-343, doi:10.1016/j.neuron.2014.06.016 (2014).
    5. Weber, R. A., Breidenbach, W. C., Brown, R. E., Jabaley, M. E. & Mass, D. P. A randomized prospective study of polyglycolic acid conduits for digital nerve reconstruction in humans. Plast Reconstr Surg 106, 1036-1045; discussion 1046-1038 (2000).
    6. Schlosshauer, B., Dreesmann, L., Schaller, H. E. & Sinis, N. Synthetic nerve guide implants in humans: a comprehensive survey. Neurosurgery 59, 740-747; discussion 747-748, doi:10.1227/01.NEU.0000235197.36789.42 (2006).
    7. Boeckstyns, M. E. et al. Collagen conduit versus microsurgical neurorrhaphy: 2-year follow-up of a prospective, blinded clinical and electrophysiological multicenter randomized, controlled trial. J Hand Surg Am 38, 2405-2411, doi:10.1016/j.jhsa.2013.09.038 (2013).
    8. Grochmal, J. & Midha, R. Recent advances in stem cell-mediated peripheral nerve repair. Cells Tissues Organs 200, 13-22, doi:10.1159/000369450 (2014).
    9. Ray, W. Z., Chang, J., Hawasli, A., Wilson, T. J. & Yang, L. Motor Nerve Transfers: A Comprehensive Review. Neurosurgery 78, 1-26, doi:10.1227/NEU.0000000000001029 (2016).
    10. Yang, L. J., Chang, K. W. & Chung, K. C. A systematic review of nerve transfer and nerve repair for the treatment of adult upper brachial plexus injury. Neurosurgery 71, 417-429; discussion 429, doi:10.1227/NEU.0b013e318257be98 (2012).
    11. Nerve regeneration in the peripheral and central nervous systemsTessa Gordon Department of Surgery, Division of Plastic Reconstructive Surgery, 06.9706 Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON, Canada, M5G 1X8, © 2016 The Authors. The Journal of Physiology C  2016 The Physiological Society, J Physiol 594.13 (2016) pp 3517–3520 (PDF)